Title : Habenular expression of rare missense variants of the β4 nicotinic receptor subunit alters nicotine consumption.

Pub. Date : 2014

PMID : 24478678






5 Functional Relationships(s)
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1 Habenular expression of rare missense variants of the beta4 nicotinic receptor subunit alters nicotine consumption. Nicotine basic helix-loop-helix family, member e23 Mus musculus
2 The CHRNA5-CHRNA3-CHRNB4 gene cluster, encoding the alpha5, alpha3, and beta4 nicotinic acetylcholine receptor (nAChR) subunits, has been linked to nicotine dependence. Nicotine basic helix-loop-helix family, member e23 Mus musculus
3 Immunoprecipitation studies confirmed that beta4 lentiviral-mediated expression leads to specific upregulation of alpha3beta4 but not beta2 nAChRs in the Mhb. 2-((3'-METHYL-4'-HYDROXYPHENYL)AZO)BENZOIC ACID basic helix-loop-helix family, member e23 Mus musculus
4 Mice injected with the beta4-containing virus showed pronounced aversion to nicotine as previously observed in transgenic Tabac mice overexpressing Chrnb4 at endogenous sites including the MHb. Nicotine basic helix-loop-helix family, member e23 Mus musculus
5 Mice injected with the beta4-containing virus showed pronounced aversion to nicotine as previously observed in transgenic Tabac mice overexpressing Chrnb4 at endogenous sites including the MHb. 2-((3'-METHYL-4'-HYDROXYPHENYL)AZO)BENZOIC ACID basic helix-loop-helix family, member e23 Mus musculus