Title : Conditional inactivation of Miwi2 reveals that MIWI2 is only essential for prospermatogonial development in mice.

Pub. Date : 2014 May

PMID : 24464225






2 Functional Relationships(s)
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1 Moreover, persistent activation of LINE1 and IAP retrotransposons caused by Miwi2 inactivation is compatible with mitotic cell cycle progression of spermatogonia during the first wave of spermatogenesis, but can cause zygotene to pachytene arrest in early meiosis due to multiple defects including enhanced DNA double-strand breaks, aberrant histone modifications and altered mRNA transcriptome. zygotene piwi-like RNA-mediated gene silencing 4 Mus musculus
2 Moreover, persistent activation of LINE1 and IAP retrotransposons caused by Miwi2 inactivation is compatible with mitotic cell cycle progression of spermatogonia during the first wave of spermatogenesis, but can cause zygotene to pachytene arrest in early meiosis due to multiple defects including enhanced DNA double-strand breaks, aberrant histone modifications and altered mRNA transcriptome. pachytene piwi-like RNA-mediated gene silencing 4 Mus musculus