Pub. Date : 2014 Jul
PMID : 24451147
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Atorvastatin prevents ATP-driven invasiveness via P2X7 and EHBP1 signaling in PTEN-expressing prostate cancer cells. | Atorvastatin | EH domain binding protein 1 | Homo sapiens |
| 2 | Atorvastatin prevents ATP-driven invasiveness via P2X7 and EHBP1 signaling in PTEN-expressing prostate cancer cells. | Adenosine Triphosphate | EH domain binding protein 1 | Homo sapiens |
| 3 | We also show that EHBP1 is essential for an anti-invasive effect of atorvastatin. | Atorvastatin | EH domain binding protein 1 | Homo sapiens |
| 4 | These data indicate that atorvastatin modulates invasiveness via P2X7, EHBP1 and P-Rex1. | Atorvastatin | EH domain binding protein 1 | Homo sapiens |
| 5 | Interestingly, the interaction between EHBP1 and P-Rex1 was not induced by extracellular adenosine triphosphate (ATP), the endogenous P2X7 ligand, and statins counteracted invasiveness stimulated by extracellular ATP. | Adenosine Triphosphate | EH domain binding protein 1 | Homo sapiens |