Pub. Date : 2014
PMID : 24416124
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A sucrose gradient fractionation experiment revealed that both Akt and Phafin2 co-existed in the same lysosome enriched fraction after autophagy induction. | Sucrose | pleckstrin homology and FYVE domain containing 2 | Homo sapiens |
| 2 | BiFC analysis using PtdIns (3)P interaction defective mutant of Phafin2 demonstrated that lysosomal accumulation of the Akt-Phafin2 complex and subsequent induction of autophagy were lysosomal PtdIns (3)P dependent events. | phosphatidylinositol 3-phosphate | pleckstrin homology and FYVE domain containing 2 | Homo sapiens |
| 3 | BiFC analysis using PtdIns (3)P interaction defective mutant of Phafin2 demonstrated that lysosomal accumulation of the Akt-Phafin2 complex and subsequent induction of autophagy were lysosomal PtdIns (3)P dependent events. | phosphatidylinositol 3-phosphate | pleckstrin homology and FYVE domain containing 2 | Homo sapiens |
| 4 | BiFC analysis using PtdIns (3)P interaction defective mutant of Phafin2 demonstrated that lysosomal accumulation of the Akt-Phafin2 complex and subsequent induction of autophagy were lysosomal PtdIns (3)P dependent events. | phosphatidylinositol 3-phosphate | pleckstrin homology and FYVE domain containing 2 | Homo sapiens |
| 5 | BiFC analysis using PtdIns (3)P interaction defective mutant of Phafin2 demonstrated that lysosomal accumulation of the Akt-Phafin2 complex and subsequent induction of autophagy were lysosomal PtdIns (3)P dependent events. | phosphatidylinositol 3-phosphate | pleckstrin homology and FYVE domain containing 2 | Homo sapiens |
| 6 | Taken together, these findings establish that lysosomal accumulation of Akt and Phafin2 is a critical step in the induction of autophagy via an interaction with PtdIns (3)P. | phosphatidylinositol 3-phosphate | pleckstrin homology and FYVE domain containing 2 | Homo sapiens |