Title : Ziv-aflibercept in metastatic colorectal cancer.

Pub. Date : 2014

PMID : 24368879






1 Functional Relationships(s)
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1 Ziv-aflibercept is a fusion protein which acts as a decoy receptor for vascular endothelial growth factor (VEGF)-A, VEGF-B, and placental growth factor (PlGF); it was approved in combination with 5-fluorouracil, leucovorin, and irinotecan (FOLFIRI) for the treatment of patients with metastatic colorectal cancer that is resistant to or has progressed after an oxaliplatin-containing fluoropyrimidine-based regimen. FOLFIRI regimen placental growth factor Homo sapiens