Pub. Date : 2014 Feb 14
PMID : 24368771
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The Cyp2c44 epoxygenase regulates epithelial sodium channel activity and the blood pressure responses to increased dietary salt. | Salts | cytochrome P450, family 2, subfamily c, polypeptide 23 | Mus musculus |
| 2 | We show here that lack of a Cyp2c44 epoxygenase causes dietary salt-sensitive hypertension, a common form of the human disease. | Salts | cytochrome P450, family 2, subfamily c, polypeptide 23 | Mus musculus |
| 3 | Cyp2c44(-/-) mice on normal salt diets are normotensive but become hypertensive when fed high salt. | Salts | cytochrome P450, family 2, subfamily c, polypeptide 23 | Mus musculus |
| 4 | Cyp2c44(-/-) mice on normal salt diets are normotensive but become hypertensive when fed high salt. | Salts | cytochrome P450, family 2, subfamily c, polypeptide 23 | Mus musculus |
| 5 | The demonstration that amiloride, an ENaC inhibitor, lowers the blood pressure of hypertensive Cyp2c44(-/-) mice identifies a role for the channel in the hypertensive phenotype of the animals. | Amiloride | cytochrome P450, family 2, subfamily c, polypeptide 23 | Mus musculus |