Pub. Date : 2013
PMID : 24349089
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hypothalamic GPR40 signaling activated by free long chain fatty acids suppresses CFA-induced inflammatory chronic pain. | long chain fatty acids | free fatty acid receptor 1 | Mus musculus |
| 2 | GPR40 has been reported to be activated by long-chain fatty acids, such as docosahexaenoic acid (DHA). | long-chain fatty acids | free fatty acid receptor 1 | Mus musculus |
| 3 | GPR40 has been reported to be activated by long-chain fatty acids, such as docosahexaenoic acid (DHA). | Docosahexaenoic Acids | free fatty acid receptor 1 | Mus musculus |
| 4 | GPR40 has been reported to be activated by long-chain fatty acids, such as docosahexaenoic acid (DHA). | Docosahexaenoic Acids | free fatty acid receptor 1 | Mus musculus |
| 5 | These increases were significantly inhibited by the intracerebroventricular injection of flavopiridol (15 nmol), a cyclin-dependent kinase inhibitor, depending on the decreases in both the increment of GPR40 protein expression and the induction of mechanical allodynia and thermal hyperalgesia at day 7 after CFA injection. | alvocidib | free fatty acid receptor 1 | Mus musculus |
| 6 | The intracerebroventricular injection of DHA (50 microg) and GW9508 (1.0 microg), a GPR40-selective agonist, significantly reduced mechanical allodynia and thermal hyperalgesia at day 7, but not at day 1, after CFA injection. | Docosahexaenoic Acids | free fatty acid receptor 1 | Mus musculus |
| 7 | The intracerebroventricular injection of DHA (50 microg) and GW9508 (1.0 microg), a GPR40-selective agonist, significantly reduced mechanical allodynia and thermal hyperalgesia at day 7, but not at day 1, after CFA injection. | GW9508 | free fatty acid receptor 1 | Mus musculus |
| 8 | These effects were inhibited by intracerebroventricular pretreatment with GW1100 (10 microg), a GPR40 antagonist. | GW1100 | free fatty acid receptor 1 | Mus musculus |
| 9 | The protein expression of GPR40 was colocalized with that of beta-endorphin and proopiomelanocortin, and a single intracerebroventricular injection of GW9508 (1.0 microg) significantly increased the number of neurons double-stained for c-Fos and proopiomelanocortin in the arcuate nucleus of the hypothalamus. | GW9508 | free fatty acid receptor 1 | Mus musculus |
| 10 | Our findings suggest that hypothalamic GPR40 activated by free long chain fatty acids might have an important role in this pain control system. | long chain fatty acids | free fatty acid receptor 1 | Mus musculus |