Title : Comparison of genome-wide DNA methylation in urothelial carcinomas of patients with and without arsenic exposure.

Pub. Date : 2014 Jan

PMID : 24268366






2 Functional Relationships(s)
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1 Significant associations between cumulative arsenic exposure and DNA methylation levels of 28 patients were observed in nine CpG sites of nine gens including PDGFD (Spearman rank correlation, 0.54), CTNNA2 (0.48), KCNK17 (0.52), PCDHB2 (0.57), ZNF132 (0.48), DCDC2 (0.48), KLK7 (0.48), FBXO39 (0.49), and NPY2R (0.45). Arsenic neuropeptide Y receptor Y2 Homo sapiens
2 CONCLUSIONS: Significant associations between cumulative arsenic exposure and methylation level of CTNNA2, KLK7, NPY2R, ZNF132 and KCNK17 were found in smoking-unrelated urothelial carcinoma. Arsenic neuropeptide Y receptor Y2 Homo sapiens