Pub. Date : 1985
PMID : 2416942
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chlordecone inhibition of calmodulin activated calcium ATPase in rat brain synaptosomes. | Chlordecone | calmodulin 1 | Rattus norvegicus |
| 2 | Chlordecone inhibited Ca2+-ATPase in the absence of calmodulin with an IC50 of 10 microM, whereas chlordecone at 1.0 microM, which had no effect on the basal enzyme activity, completely inhibited the calmodulin activated Ca2+-ATPase. | Chlordecone | calmodulin 1 | Rattus norvegicus |
| 3 | Chlordecone inhibited Ca2+-ATPase in the absence of calmodulin with an IC50 of 10 microM, whereas chlordecone at 1.0 microM, which had no effect on the basal enzyme activity, completely inhibited the calmodulin activated Ca2+-ATPase. | Chlordecone | calmodulin 1 | Rattus norvegicus |
| 4 | Chlordecone-treated rats showed a significant reduction in calmodulin levels in brain P2 fraction. | Chlordecone | calmodulin 1 | Rattus norvegicus |
| 5 | Brain synaptosomal Ca2+-ATPase in chlordecone-treated rats showed a 50% reduction, which was restored by exogenously added calmodulin. | Chlordecone | calmodulin 1 | Rattus norvegicus |
| 6 | These results suggest that chlordecone may be altering calmodulin-regulated synaptic processes in the brain. | Chlordecone | calmodulin 1 | Rattus norvegicus |