Title : Lack of CD47 impairs bone cell differentiation and results in an osteopenic phenotype in vivo due to impaired signal regulatory protein α (SIRPα) signaling.

Pub. Date : 2013 Oct 11

PMID : 23990469






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In parathyroid hormone or 1alpha,25(OH)2-vitamin D3 (D3)-stimulated bone marrow cultures (BMC) from CD47(-/-) mice, we found a strongly reduced formation of multinuclear tartrate-resistant acid phosphatase (TRAP)(+) osteoclasts, associated with reduced expression of osteoclastogenic genes (nfatc1, Oscar, Trap/Acp, ctr, catK, and dc-stamp). 25(oh)2-vitamin d3 calcitonin receptor Mus musculus