Pub. Date : 2013 May 27
PMID : 23706078
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Celastrol induces apoptosis of gastric cancer cells by miR-146a inhibition of NF-kappaB activity. | celastrol | microRNA 146a | Homo sapiens |
| 2 | Finally, the effect of miR-146a on celastrol-induced anti-tumor activity was assessed using miR-146a inhibitor. | celastrol | microRNA 146a | Homo sapiens |
| 3 | Finally, the effect of miR-146a on celastrol-induced anti-tumor activity was assessed using miR-146a inhibitor. | celastrol | microRNA 146a | Homo sapiens |
| 4 | Furthermore, Celastrol could increase miR-146a expression and up-regulation of miR-146a expression could suppress NF-kappaB activity. | celastrol | microRNA 146a | Homo sapiens |
| 5 | More important, down-regulation of miR-146a expression can reverse the effect of celastrol on NF-kappaB activity and apoptosis in gastric cancer cells. | celastrol | microRNA 146a | Homo sapiens |
| 6 | CONCLUSIONS: In this study, we demonstrated that the effect of celastrol on apoptosis is due to miR-146a inhibition of NF-kappaB activity. | celastrol | microRNA 146a | Homo sapiens |