Pub. Date : 1990
PMID : 2369550
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Reductions in gamma-globin mRNA levels restricted to the cytoplasm of 5-fluorouridine treated K-562 human erythroleukemia cells. | 5-fluorouridine | hemoglobin subunit gamma 1 | Homo sapiens |
| 2 | In this report, we demonstrate that gamma-globin mRNA species were decreased by as much as 40% within 2 hr of exposure to micromolar concentrations of FUrd. | 5-fluorouridine | hemoglobin subunit gamma 1 | Homo sapiens |
| 3 | Thus, the decrease was not accounted for by drug-induced inhibition of new gamma-globin mRNA synthesis or misincorporation but must have been due to an FUrd-induced increase in gamma-globin mRNA degradation. | 5-fluorouridine | hemoglobin subunit gamma 1 | Homo sapiens |