Title : Safety, pharmacokinetics, and pharmacodynamics of the DR5 antibody LBY135 alone and in combination with capecitabine in patients with advanced solid tumors.

Pub. Date : 2014 Feb

PMID : 23589214






1 Functional Relationships(s)
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1 In Arm2 (n = 33), LBY135 (1-40 mg/kg) plus capecitabine resulted in 3 DLTs (each grade 3): dehydration and mucosal inflammation (1 mg/kg), colitis (20 mg/kg), and diarrhea (40 mg/kg). lby135 Jupiter microtubule associated homolog 1 Homo sapiens