Pub. Date : 2013 Jul
PMID : 23564016
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nitrogen-containing bisphosphonates have been well known to be inhibited farnesyl diphosphate synthase (FDPS), an enzyme in mevalonic acid metabolism, resulting in disturbance in polymerization of cytoskeleton structure in bone resorption and promotion of apoptosis in mature osteoclasts. | Nitrogen | farnesyl diphosphate synthetase | Mus musculus |
| 2 | Nitrogen-containing bisphosphonates have been well known to be inhibited farnesyl diphosphate synthase (FDPS), an enzyme in mevalonic acid metabolism, resulting in disturbance in polymerization of cytoskeleton structure in bone resorption and promotion of apoptosis in mature osteoclasts. | Nitrogen | farnesyl diphosphate synthetase | Mus musculus |
| 3 | Nitrogen-containing bisphosphonates have been well known to be inhibited farnesyl diphosphate synthase (FDPS), an enzyme in mevalonic acid metabolism, resulting in disturbance in polymerization of cytoskeleton structure in bone resorption and promotion of apoptosis in mature osteoclasts. | Diphosphonates | farnesyl diphosphate synthetase | Mus musculus |
| 4 | Nitrogen-containing bisphosphonates have been well known to be inhibited farnesyl diphosphate synthase (FDPS), an enzyme in mevalonic acid metabolism, resulting in disturbance in polymerization of cytoskeleton structure in bone resorption and promotion of apoptosis in mature osteoclasts. | Diphosphonates | farnesyl diphosphate synthetase | Mus musculus |
| 5 | Nitrogen-containing bisphosphonates have been well known to be inhibited farnesyl diphosphate synthase (FDPS), an enzyme in mevalonic acid metabolism, resulting in disturbance in polymerization of cytoskeleton structure in bone resorption and promotion of apoptosis in mature osteoclasts. | Mevalonic Acid | farnesyl diphosphate synthetase | Mus musculus |
| 6 | Nitrogen-containing bisphosphonates have been well known to be inhibited farnesyl diphosphate synthase (FDPS), an enzyme in mevalonic acid metabolism, resulting in disturbance in polymerization of cytoskeleton structure in bone resorption and promotion of apoptosis in mature osteoclasts. | Mevalonic Acid | farnesyl diphosphate synthetase | Mus musculus |
| 7 | Tetracycline-induced FDPS silencing caused a significant decrease in the Cl(-) current. | Tetracycline | farnesyl diphosphate synthetase | Mus musculus |
| 8 | These results suggest that nitrogen-containing bisphosphonates suppress the activity of osteoclastic acid-activated Cl(-) currents through FDPS inhibition, suggesting the inhibition of Cl(-) extrusion activity. | Nitrogen | farnesyl diphosphate synthetase | Mus musculus |
| 9 | These results suggest that nitrogen-containing bisphosphonates suppress the activity of osteoclastic acid-activated Cl(-) currents through FDPS inhibition, suggesting the inhibition of Cl(-) extrusion activity. | Diphosphonates | farnesyl diphosphate synthetase | Mus musculus |