Title : Cellular overexpression of aquaporins slows down the natural HIF-2α degradation during prolonged hypoxia.

Pub. Date : 2013 Jun 10

PMID : 23545307






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Levels of HIF target genes (PHD2 and 3, VEGF, and PGK1) were 2-4 fold higher in hypoxic o-AQP-c than in wt-PC12 cells, and morphological changes in colony shape together with higher cell proliferation rates were observed in all o-AQP-c. Interestingly, analysis of PHD levels under normoxia revealed lower (50%) PHD3 expression in o-AQP-c than in controls. o-aqp egl-9 family hypoxia-inducible factor 1 Rattus norvegicus
2 Levels of HIF target genes (PHD2 and 3, VEGF, and PGK1) were 2-4 fold higher in hypoxic o-AQP-c than in wt-PC12 cells, and morphological changes in colony shape together with higher cell proliferation rates were observed in all o-AQP-c. Interestingly, analysis of PHD levels under normoxia revealed lower (50%) PHD3 expression in o-AQP-c than in controls. o-aqp egl-9 family hypoxia-inducible factor 1 Rattus norvegicus