Title : MicroRNA-195 protects against dementia induced by chronic brain hypoperfusion via its anti-amyloidogenic effect in rats.

Pub. Date : 2013 Feb 27

PMID : 23447608






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We show here that CBH generated by bilateral common carotid artery occlusion (2VO) significantly decreased the learning and memory ability in rats, as assessed by Morris water maze, and upregulated expression of APP and BACE1 proteins in the hippocampus and cortex of rats, as evaluated by Western blot and immunofluorescence. S-(D-CARBOXYBUTYL)-L-HOMOCYSTEINE beta-secretase 1 Rattus norvegicus
2 In reciprocal, qRT-PCR analysis showed that microRNA-195 (miR-195) was downregulated in both the hippocampus and cortex of rats following CBH, and in the plasma of dementia patients. S-(D-CARBOXYBUTYL)-L-HOMOCYSTEINE microRNA 195 Rattus norvegicus
3 In reciprocal, qRT-PCR analysis showed that microRNA-195 (miR-195) was downregulated in both the hippocampus and cortex of rats following CBH, and in the plasma of dementia patients. S-(D-CARBOXYBUTYL)-L-HOMOCYSTEINE microRNA 195 Rattus norvegicus