Pub. Date : 2013
PMID : 23405127
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Addition of physiological concentrations of dihydrotestosterone (DHT) to prostate cancer cell lines increases translation of endogenous TMEFF2 or transfected TMEFF2-Luciferase fusions, and this effect requires the presence of upstream open reading frames (uORFs) in the 5"-untranslated region (5"-UTR) of TMEFF2. | Dihydrotestosterone | transmembrane protein with EGF like and two follistatin like domains 2 | Homo sapiens |
| 2 | Addition of physiological concentrations of dihydrotestosterone (DHT) to prostate cancer cell lines increases translation of endogenous TMEFF2 or transfected TMEFF2-Luciferase fusions, and this effect requires the presence of upstream open reading frames (uORFs) in the 5"-untranslated region (5"-UTR) of TMEFF2. | Dihydrotestosterone | transmembrane protein with EGF like and two follistatin like domains 2 | Homo sapiens |
| 3 | Addition of physiological concentrations of dihydrotestosterone (DHT) to prostate cancer cell lines increases translation of endogenous TMEFF2 or transfected TMEFF2-Luciferase fusions, and this effect requires the presence of upstream open reading frames (uORFs) in the 5"-untranslated region (5"-UTR) of TMEFF2. | Dihydrotestosterone | transmembrane protein with EGF like and two follistatin like domains 2 | Homo sapiens |
| 4 | Addition of physiological concentrations of dihydrotestosterone (DHT) to prostate cancer cell lines increases translation of endogenous TMEFF2 or transfected TMEFF2-Luciferase fusions, and this effect requires the presence of upstream open reading frames (uORFs) in the 5"-untranslated region (5"-UTR) of TMEFF2. | Dihydrotestosterone | transmembrane protein with EGF like and two follistatin like domains 2 | Homo sapiens |
| 5 | Addition of physiological concentrations of dihydrotestosterone (DHT) to prostate cancer cell lines increases translation of endogenous TMEFF2 or transfected TMEFF2-Luciferase fusions, and this effect requires the presence of upstream open reading frames (uORFs) in the 5"-untranslated region (5"-UTR) of TMEFF2. | Dihydrotestosterone | transmembrane protein with EGF like and two follistatin like domains 2 | Homo sapiens |
| 6 | Addition of physiological concentrations of dihydrotestosterone (DHT) to prostate cancer cell lines increases translation of endogenous TMEFF2 or transfected TMEFF2-Luciferase fusions, and this effect requires the presence of upstream open reading frames (uORFs) in the 5"-untranslated region (5"-UTR) of TMEFF2. | Dihydrotestosterone | transmembrane protein with EGF like and two follistatin like domains 2 | Homo sapiens |
| 7 | Importantly, DHT also promotes phosphorylation of the alpha subunit of the translation initiation factor 2 (eIF2alpha) in an AR-dependent manner, paralleling the effect on TMEFF2 translation. | Dihydrotestosterone | transmembrane protein with EGF like and two follistatin like domains 2 | Homo sapiens |