Pub. Date : 2013 Jun
PMID : 23331570
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AIMS: G protein-coupled receptor/free fatty acid receptor 1 (GPR40/FFAR1 ) regulates free fatty acid-induced insulin secretion. | Fatty Acids, Nonesterified | free fatty acid receptor 1 | Mus musculus |
| 2 | AIMS: G protein-coupled receptor/free fatty acid receptor 1 (GPR40/FFAR1 ) regulates free fatty acid-induced insulin secretion. | Fatty Acids, Nonesterified | free fatty acid receptor 1 | Mus musculus |
| 3 | RESULTS: GPR40/FFAR1 KO mice kept on a high-fat diet became obese, developed glucose intolerance to a similar degree as GPR40/FFAR1 wild-type (WT) mice. | Glucose | free fatty acid receptor 1 | Mus musculus |
| 4 | CONCLUSIONS: GPR40/FFAR1 has a major role in regulating fatty-acid-mediated insulin secretion, but the lack of GPR40/FFAR1 does not exacerbate glucose intolerance and insulin resistance induced by high-fat diet or diabetogenic KK gene. | Fatty Acids | free fatty acid receptor 1 | Mus musculus |
| 5 | CONCLUSIONS: GPR40/FFAR1 has a major role in regulating fatty-acid-mediated insulin secretion, but the lack of GPR40/FFAR1 does not exacerbate glucose intolerance and insulin resistance induced by high-fat diet or diabetogenic KK gene. | Fatty Acids | free fatty acid receptor 1 | Mus musculus |