Pub. Date : 2013 Feb 28
PMID : 23305840
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | FGF21 suppresses hepatic glucose production through the activation of atypical protein kinase Ciota/lambda. | Glucose | fibroblast growth factor 21 | Rattus norvegicus |
| 2 | Previous studies have demonstrated that FGF21 inhibits glucose output in the rat H4IIE hepatoma cell line. | Glucose | fibroblast growth factor 21 | Rattus norvegicus |
| 3 | We performed pharmacological studies to investigate the mechanisms by which FGF21 regulates glucose production in these cells. | Glucose | fibroblast growth factor 21 | Rattus norvegicus |
| 4 | Additionally, we found that FGF21 induced PKCiota/lambda phosphorylation in a PI3K-dependent manner; and that a non-isoform selective PKC inhibitor blocked FGF21 inhibition of glucose production, while an inhibitor of classical and novel PKC isoforms had no effect on FGF21 inhibitory activity. | Glucose | fibroblast growth factor 21 | Rattus norvegicus |
| 5 | Additionally, we found that FGF21 induced PKCiota/lambda phosphorylation in a PI3K-dependent manner; and that a non-isoform selective PKC inhibitor blocked FGF21 inhibition of glucose production, while an inhibitor of classical and novel PKC isoforms had no effect on FGF21 inhibitory activity. | Glucose | fibroblast growth factor 21 | Rattus norvegicus |
| 6 | Additionally, we found that FGF21 induced PKCiota/lambda phosphorylation in a PI3K-dependent manner; and that a non-isoform selective PKC inhibitor blocked FGF21 inhibition of glucose production, while an inhibitor of classical and novel PKC isoforms had no effect on FGF21 inhibitory activity. | Glucose | fibroblast growth factor 21 | Rattus norvegicus |