Title : Cardiac-specific overexpression of farnesyl pyrophosphate synthase induces cardiac hypertrophy and dysfunction in mice.

Pub. Date : 2013 Mar 1

PMID : 23180723






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 AIMS: Farnesyl pyrophosphate synthase (FPPS) is a key enzyme in the mevalonate pathway. Mevalonic Acid farnesyl diphosphate synthetase Mus musculus
2 AIMS: Farnesyl pyrophosphate synthase (FPPS) is a key enzyme in the mevalonate pathway. Mevalonic Acid farnesyl diphosphate synthetase Mus musculus
3 The results showed that Tg mice with overexpression of FPPS exhibited cardiac hypertrophy, fibrosis, and HF, as well as increased synthesis of farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate in heart tissue. farnesyl pyrophosphate farnesyl diphosphate synthetase Mus musculus
4 The results showed that Tg mice with overexpression of FPPS exhibited cardiac hypertrophy, fibrosis, and HF, as well as increased synthesis of farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate in heart tissue. geranylgeranyl pyrophosphate farnesyl diphosphate synthetase Mus musculus