Title : TIS21(/BTG2/PC3) accelerates the repair of DNA double strand breaks by enhancing Mre11 methylation and blocking damage signal transfer to the Chk2(T68)-p53(S20) pathway.

Pub. Date : 2012 Dec 1

PMID : 23089312






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Adenoviral transduction of Huh7 tumor cells with the TIS21 gene accelerated the repair of DSBs induced by etoposide treatment as evaluated by clearance of gammaH2AX foci and the Comet assay. dsbs BTG anti-proliferation factor 2 Homo sapiens
2 Adenoviral transduction of Huh7 tumor cells with the TIS21 gene accelerated the repair of DSBs induced by etoposide treatment as evaluated by clearance of gammaH2AX foci and the Comet assay. Etoposide BTG anti-proliferation factor 2 Homo sapiens
3 Expression of TIS21 promoted the repair of DSBs and reduced apoptosis by blocking the damage signal from p-ATM(S1981) to Chk2(T68)-p53(S20)via the activation of Mre11 and PRMT1. dsbs BTG anti-proliferation factor 2 Homo sapiens