Pub. Date : 2012 Dec 1
PMID : 23036320
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ahr2-dependence of PCB126 effects on the swim bladder in relation to expression of CYP1 and cox-2 genes in developing zebrafish. | 3,4,5,3',4'-pentachlorobiphenyl | aryl hydrocarbon receptor 2 | Danio rerio |
| 2 | Both swim bladder and lung are developmental targets of persistent aryl hydrocarbon receptor (AHR(2)) agonists; in zebrafish (Danio rerio) the swim bladder fails to inflate with exposure to 3,3",4,4",5-pentachlorobiphenyl (PCB126). | 3,4,5,3',4'-pentachlorobiphenyl | aryl hydrocarbon receptor 2 | Danio rerio |
| 3 | Ahr2-morpholino treatment rescued the effect of PCB126 (5 nM) on swim bladder inflation and blocked induction of CYP1A, cox-2a, and cox-2b. | 3,4,5,3',4'-pentachlorobiphenyl | aryl hydrocarbon receptor 2 | Danio rerio |
| 4 | Our results indicate that PCB126 blocks swim bladder inflation via an Ahr2-mediated mechanism. | 3,4,5,3',4'-pentachlorobiphenyl | aryl hydrocarbon receptor 2 | Danio rerio |