Pub. Date : 2013 Jul 11
PMID : 22869149
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A whole genome microarray analysis, using a BT474 cell line, reveals genes significantly modulated (positively or negatively) after LMTK3 silencing, including some that are known to be implicated in Tam resistance, notably c-MYC, HSPB8 and SIAH2. | Tamoxifen | lemur tyrosine kinase 3 | Homo sapiens |
| 2 | We show that LMTK3 is able to increase the levels of HSPB8 at a transcriptional and translational level thereby protecting MCF7 cells from Tam-induced cell death, by reducing autophagy. | Tamoxifen | lemur tyrosine kinase 3 | Homo sapiens |
| 3 | Finally, high LMTK3 levels at baseline in tumors are predictive for endocrine resistance; therapy does not lead to alteration in levels, whereas in patient"s plasma samples, acquired LMTK3 gene amplification (copy number variation) was associated with relapse while receiving Tam. | Tamoxifen | lemur tyrosine kinase 3 | Homo sapiens |
| 4 | Finally, high LMTK3 levels at baseline in tumors are predictive for endocrine resistance; therapy does not lead to alteration in levels, whereas in patient"s plasma samples, acquired LMTK3 gene amplification (copy number variation) was associated with relapse while receiving Tam. | Tamoxifen | lemur tyrosine kinase 3 | Homo sapiens |