Title : Downregulation of miR-205 modulates cell susceptibility to oxidative and endoplasmic reticulum stresses in renal tubular cells.

Pub. Date : 2012

PMID : 22859986






3 Functional Relationships(s)
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1 Functional analysis revealed that decreased miR-205 led to an increase in cell susceptibility to oxidative and ER stresses, and that this increase was associated with the induction of intracellular ROS and suppression of anti-oxidant enzymes. Reactive Oxygen Species microRNA 205 Homo sapiens
2 Further, miR-205 bound to the 3"-UTR of the prolyl hydroxylase 1 (PHD1/EGLN2) gene and suppressed the transcription level of EGLN2, which modulates both intracellular ROS level and ER stress state. Reactive Oxygen Species microRNA 205 Homo sapiens
3 CONCLUSIONS: miR-205 serves a protective role against both oxidative and ER stresses via the suppression of EGLN2 and subsequent decrease in intracellular ROS. Reactive Oxygen Species microRNA 205 Homo sapiens