Title : Organic anion-transporting polypeptides 1a/1b control the hepatic uptake of pravastatin in mice.

Pub. Date : 2012 Sep 4

PMID : 22812517






1 Functional Relationships(s)
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1 Activity-reducing human OATP1B polymorphisms may therefore both reduce pravastatin therapeutic efficacy in the liver and increase systemic toxicity risks, thus compromising its therapeutic index in a two-edged way. Pravastatin ornithine aminotransferase pseudogene 1 Homo sapiens