Title : Modification of mucin gene expression in the airways of rats exposed to sulfur dioxide.

Pub. Date : 1990

PMID : 2261514






4 Functional Relationships(s)
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Compound Name
Protein Name
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1 Modification of mucin gene expression in the airways of rats exposed to sulfur dioxide. Sulfur Dioxide solute carrier family 13 member 2 Rattus norvegicus
2 We are investigating this possibility by monitoring steady state levels of mucin mRNA in a model of mucous cell metaplasia induced by SO2 exposure. Sulfur Dioxide solute carrier family 13 member 2 Rattus norvegicus
3 Densitometry values normalized for the amount of RNA loaded per lane (as determined by actin hybridization intensity) showed that mucin mRNA increased 8-9 fold as a function of SO2 exposure. Sulfur Dioxide solute carrier family 13 member 2 Rattus norvegicus
4 This is consistent with the possibility that mucin gene transcription is induced by SO2 exposure, and may represent a primary event in the development of mucous metaplasia and hypersecretion. Sulfur Dioxide solute carrier family 13 member 2 Rattus norvegicus