Title : The Anx7(+/-) knockout mutation alters electrical and secretory responses to Ca(2+)-mobilizing agents in pancreatic β-cells.

Pub. Date : 2012

PMID : 22613970






5 Functional Relationships(s)
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1 We have previously shown that beta-cells of mice lacking one copy of the Annexin 7 gene (Anx7(+/-)) express reduced levels of IP(3) receptors and defects in IP(3)-dependent Ca(2+) signaling. ip annexin A7 Mus musculus
2 We have previously shown that beta-cells of mice lacking one copy of the Annexin 7 gene (Anx7(+/-)) express reduced levels of IP(3) receptors and defects in IP(3)-dependent Ca(2+) signaling. ip annexin A7 Mus musculus
3 We found that the muscarinic agonist carbachol and the ryanodine receptor agonists caffeine and 4-chloro-m-cresol had more potent depolarizing effects on Anx7(+/-) beta-cells compared to controls. Carbachol annexin A7 Mus musculus
4 We found that the muscarinic agonist carbachol and the ryanodine receptor agonists caffeine and 4-chloro-m-cresol had more potent depolarizing effects on Anx7(+/-) beta-cells compared to controls. Caffeine annexin A7 Mus musculus
5 We found that the muscarinic agonist carbachol and the ryanodine receptor agonists caffeine and 4-chloro-m-cresol had more potent depolarizing effects on Anx7(+/-) beta-cells compared to controls. chlorocresol annexin A7 Mus musculus