Title : Mice lacking the β4 subunit of the nicotinic acetylcholine receptor show memory deficits, altered anxiety- and depression-like behavior, and diminished nicotine-induced analgesia.

Pub. Date : 2012 Nov

PMID : 22573727






3 Functional Relationships(s)
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Protein Name
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1 Mice lacking the beta4 subunit of the nicotinic acetylcholine receptor show memory deficits, altered anxiety- and depression-like behavior, and diminished nicotine-induced analgesia. Nicotine basic helix-loop-helix family, member e23 Mus musculus
2 beta4(-/-) mice did not differ from beta4(+/+) mice in basal nociception but were less sensitive to the antinociceptive effect of nicotine in 2 tests of acute thermal pain. Nicotine basic helix-loop-helix family, member e23 Mus musculus
3 beta4-containing nAChRs are involved in anxiety- and depression-like behaviors and contribute to the analgesic effects of nicotine. Nicotine basic helix-loop-helix family, member e23 Mus musculus