Title : Slow tight-binding inhibition of prolyl endopeptidase by benzyloxycarbonyl-prolyl-prolinal.

Pub. Date : 1990 Oct 15

PMID : 2241932






3 Functional Relationships(s)
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1 41, 69-75] have shown that benzyloxycarbonyl-prolyl-prolinal (Z-prolyl-prolinal) is a potent inhibitor of prolyl endopeptidase. N-benzyloxycarbonylprolylprolinal prolyl endopeptidase Mus musculus
2 We show that Z-prolyl-prolinal is a slow-binding inhibitor of mouse brain prolyl endopeptidase with Ki 0.35 +/- 0.05 nM. N-benzyloxycarbonylprolylprolinal prolyl endopeptidase Homo sapiens
3 Prolyl endopeptidase from human brain is also inhibited by Z-prolyl-prolinal with kinetics similar to those of the mouse brain enzyme. N-benzyloxycarbonylprolylprolinal prolyl endopeptidase Homo sapiens