Title : NF-κB-mediated degradation of the coactivator RIP140 regulates inflammatory responses and contributes to endotoxin tolerance.

Pub. Date : 2012 Mar 4

PMID : 22388040






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Here we found lipopolysaccharide stimulation of kinase Syk-mediated tyrosine phosphorylation of RIP140 and interaction of the NF-kappaB subunit RelA with RIP140. Tyrosine nuclear receptor interacting protein 1 Homo sapiens
2 These events resulted in more recruitment of the E3 ligase SCF to tyrosine-phosphorylated RIP140, which degraded RIP140 to inactivate genes encoding inflammatory cytokines. Tyrosine nuclear receptor interacting protein 1 Homo sapiens
3 These events resulted in more recruitment of the E3 ligase SCF to tyrosine-phosphorylated RIP140, which degraded RIP140 to inactivate genes encoding inflammatory cytokines. Tyrosine nuclear receptor interacting protein 1 Homo sapiens