Pub. Date : 2012 Feb 15
PMID : 22116304
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | L-Mimosine blocks cell proliferation via upregulation of B-cell translocation gene 2 and N-myc downstream regulated gene 1 in prostate carcinoma cells. | Mimosine | BTG anti-proliferation factor 2 | Homo sapiens |
| 2 | We evaluated the molecular mechanisms of L-mimosine on cell cycle modulation in PC-3 and LNCaP prostate carcinoma cells. | Mimosine | BTG anti-proliferation factor 2 | Homo sapiens |
| 3 | L-Mimosine arrested the cell cycle at the G1 phase in PC-3 cells and at the S phase in LNCaP cells, thus attenuating cell proliferation. | Mimosine | BTG anti-proliferation factor 2 | Homo sapiens |
| 4 | Immunoblot assays indicated that hypoxia and L-mimosine stabilized hypoxia-inducible factor-1alpha (HIF-1alpha) and induced Btg2 and Ndrg1 protein expression, but downregulated protein levels of cyclin A in both PC-3 and LNCaP cells. | Mimosine | BTG anti-proliferation factor 2 | Homo sapiens |
| 5 | Immunoblot assays indicated that hypoxia and L-mimosine stabilized hypoxia-inducible factor-1alpha (HIF-1alpha) and induced Btg2 and Ndrg1 protein expression, but downregulated protein levels of cyclin A in both PC-3 and LNCaP cells. | Mimosine | BTG anti-proliferation factor 2 | Homo sapiens |
| 6 | L-Mimosine treatment decreased cyclin D1 protein in PC-3 cells, but not in LNCaP cells. | Mimosine | BTG anti-proliferation factor 2 | Homo sapiens |
| 7 | Dimethyloxalylglycine, a pan-prolyl hydroxylase inhibitor, also induced Btg2 and Ndrg1 protein expression in LNCaP cells. | oxalylglycine | BTG anti-proliferation factor 2 | Homo sapiens |
| 8 | The transient gene expression assay revealed that L-mimosine treatment or cotransfection with HIF-1alpha expression vector enhanced the promoter activities of Btg2 and Ndrg1 genes. | Mimosine | BTG anti-proliferation factor 2 | Homo sapiens |
| 9 | Knockdown of HIF-1alpha attenuated the increasing protein levels of both Btg2 and Ndrg1 by hypoxia or L-mimosine in LNCaP cells. | Mimosine | BTG anti-proliferation factor 2 | Homo sapiens |
| 10 | Our results indicated that hypoxia and L-mimosine modulated Btg2 and Ndrg1 at the transcriptional level, which is dependent on HIF-1alpha. | Mimosine | BTG anti-proliferation factor 2 | Homo sapiens |
| 11 | L-Mimosine enhanced expression of Btg2 and Ndrg1, which attenuated cell proliferation of the PC-3 and LNCaP prostate carcinoma cells. | Mimosine | BTG anti-proliferation factor 2 | Homo sapiens |
| 12 | L-Mimosine enhanced expression of Btg2 and Ndrg1, which attenuated cell proliferation of the PC-3 and LNCaP prostate carcinoma cells. | Mimosine | BTG anti-proliferation factor 2 | Homo sapiens |