Title : The TM2 6' position of GABA(A) receptors mediates alcohol inhibition.

Pub. Date : 2012 Feb

PMID : 22072732






3 Functional Relationships(s)
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1 Labeling of the 6" position in either alpha2 or beta2 subunits reduced responses to GABA. gamma-Aminobutyric Acid MGC75582, possible similarity to act2 S homeolog Xenopus laevis
2 These results indicate that the 6" positions in both alpha2 and beta2 GABA(A)R subunits mediate inhibition by short-chain alcohols, which is consistent with the presence of multiple counteracting sites of action for alcohols on ligand-gated ion channels. Alcohols MGC75582, possible similarity to act2 S homeolog Xenopus laevis
3 These results indicate that the 6" positions in both alpha2 and beta2 GABA(A)R subunits mediate inhibition by short-chain alcohols, which is consistent with the presence of multiple counteracting sites of action for alcohols on ligand-gated ion channels. Alcohols MGC75582, possible similarity to act2 S homeolog Xenopus laevis