Title : Aryl hydrocarbon receptor modulation of estrogen receptor α-mediated gene regulation by a multimeric chromatin complex involving the two receptors and the coregulator RIP140.

Pub. Date : 2012 Feb

PMID : 22071320






3 Functional Relationships(s)
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1 Changing the cellular level of RIP140 revealed coactivator or corepressor roles for this coregulator in E2- and dioxin-mediated gene regulation, the choice of which was determined by the presence or absence of ERalpha at gene regulatory sites. Dioxins nuclear receptor interacting protein 1 Homo sapiens
2 Coimmunoprecipitation and chromatin immunoprecipitation (ChIP)-reChIP studies documented that E2- or dioxin-promoted formation of a multimeric complex of ERalpha, AhR, and RIP140 at ERalpha-binding sites of genes regulated by either E2 or dioxin. Dioxins nuclear receptor interacting protein 1 Homo sapiens
3 Coimmunoprecipitation and chromatin immunoprecipitation (ChIP)-reChIP studies documented that E2- or dioxin-promoted formation of a multimeric complex of ERalpha, AhR, and RIP140 at ERalpha-binding sites of genes regulated by either E2 or dioxin. Dioxins nuclear receptor interacting protein 1 Homo sapiens