Pub. Date : 2011 Dec 1
PMID : 21964300
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cardiac toxicity of 5-ring polycyclic aromatic hydrocarbons is differentially dependent on the aryl hydrocarbon receptor 2 isoform during zebrafish development. | Polycyclic Aromatic Hydrocarbons | aryl hydrocarbon receptor 2 | Danio rerio |
| 2 | BaP exposure (40muM) produced AHR2-dependent bradycardia, pericardial edema, and myocardial CYP1A immunofluorescence. | Benzo(a)pyrene | aryl hydrocarbon receptor 2 | Danio rerio |
| 3 | By contrast, BkF exposure (4-40muM) caused more severe pericardial edema, looping defects, and erythrocyte regurgitation through the atrioventricular valve that were AHR2-independent (i.e., absent myocardial or endocardial CYP1A induction). | benzo(k)fluoranthene | aryl hydrocarbon receptor 2 | Danio rerio |