Title : CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction.

Pub. Date : 2012 Feb

PMID : 21953249






2 Functional Relationships(s)
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1 Live cell microscopy analysis revealed that CERT depletion induces LAMP2-dependent death of polyploid cells following exit from mitosis in the presence of paclitaxel. Paclitaxel lysosomal associated membrane protein 2 Homo sapiens
2 These data suggest that the induction of LAMP2-dependent autophagic flux through CERT targeting may provide a rational approach to enhance multidrug sensitization and potentiate the death of polyploid cells following paclitaxel exposure to limit the acquisition of CIN and intra-tumour heterogeneity. Paclitaxel lysosomal associated membrane protein 2 Homo sapiens