Pub. Date : 2012 Feb
PMID : 21948871
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | An overlay binding assay revealed that ZG16p binds specifically to heparan sulfate PGs by recognizing their GAG chains. | Heparitin Sulfate | zymogen granule protein 16 | Rattus norvegicus |
| 2 | An overlay binding assay revealed that ZG16p binds specifically to heparan sulfate PGs by recognizing their GAG chains. | Glycosaminoglycans | zymogen granule protein 16 | Rattus norvegicus |
| 3 | Affinity chromatography demonstrated that ZG16p binds most strongly to heparin among the zymogen granule proteins. | Heparin | zymogen granule protein 16 | Rattus norvegicus |
| 4 | Site-directed mutational analysis revealed that the basic amino acid residues located in two putative carbohydrate-binding sites (CBSs) of ZG16p, which were found in association with the crystal structure of BanLec, are responsible for the recognition of heparin. | Amino Acids, Basic | zymogen granule protein 16 | Rattus norvegicus |
| 5 | Site-directed mutational analysis revealed that the basic amino acid residues located in two putative carbohydrate-binding sites (CBSs) of ZG16p, which were found in association with the crystal structure of BanLec, are responsible for the recognition of heparin. | Carbohydrates | zymogen granule protein 16 | Rattus norvegicus |
| 6 | Site-directed mutational analysis revealed that the basic amino acid residues located in two putative carbohydrate-binding sites (CBSs) of ZG16p, which were found in association with the crystal structure of BanLec, are responsible for the recognition of heparin. | Heparin | zymogen granule protein 16 | Rattus norvegicus |
| 7 | These observations suggest that ZG16p is the primary binding partner of the granule heparan sulfate PGs. | Heparitin Sulfate | zymogen granule protein 16 | Rattus norvegicus |
| 8 | ZG16p may cross-link the granule heparan sulfate chains via two CBSs and facilitate the formation of a submembranous matrix, a sorting platform for enzyme proteins on the luminal side of the zymogen granule membrane. | Heparitin Sulfate | zymogen granule protein 16 | Rattus norvegicus |