Title : Latent membrane protein 1 of Epstein-Barr virus sensitizes cancer cells to cisplatin by enhancing NF-κB p50 homodimer formation and downregulating NAPA expression.

Pub. Date : 2011 Dec 15

PMID : 21945668






3 Functional Relationships(s)
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1 In the present study, we found that LMP1 inhibits the expression of NAPA, an endoplasmic reticulum SNARE protein that possesses anti-apoptotic properties against the DNA-damaging drug cisplatin. Acecainide PDZ and LIM domain 7 Homo sapiens
2 Similarly, overexpression of NAPA reduced the effect of LMP1 and induced resistance to cisplatin. Acecainide PDZ and LIM domain 7 Homo sapiens
3 These findings suggest that the viral protein LMP1 may sensitize cancer cells to cisplatin chemotherapy by downregulating NAPA and by enhancing the formation of p50 homodimers which in turn inhibit the expression of NF-kappaB regulated anti-apoptotic genes. Acecainide PDZ and LIM domain 7 Homo sapiens