Title : 3-Hydroxy-2'-methoxy-6-methylflavone: a potent anxiolytic with a unique selectivity profile at GABA(A) receptor subtypes.

Pub. Date : 2011 Dec 15

PMID : 21924247






4 Functional Relationships(s)
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1 Here we demonstrate that the synthetic flavonoid, 3-hydroxy-2"-methoxy-6-methylflavone (3-OH-2"MeO6MF) potentiates GABA-induced currents at recombinant alpha1/2beta2, alpha1/2/4/6beta1-3gamma2L but not alpha3/5beta1-3gamma2L receptors expressed in Xenopus oocytes. Flavonoids MGC75582, possible similarity to act2 S homeolog Xenopus laevis
2 Here we demonstrate that the synthetic flavonoid, 3-hydroxy-2"-methoxy-6-methylflavone (3-OH-2"MeO6MF) potentiates GABA-induced currents at recombinant alpha1/2beta2, alpha1/2/4/6beta1-3gamma2L but not alpha3/5beta1-3gamma2L receptors expressed in Xenopus oocytes. 3-hydroxy-2'-methoxy-6-methylflavone MGC75582, possible similarity to act2 S homeolog Xenopus laevis
3 Here we demonstrate that the synthetic flavonoid, 3-hydroxy-2"-methoxy-6-methylflavone (3-OH-2"MeO6MF) potentiates GABA-induced currents at recombinant alpha1/2beta2, alpha1/2/4/6beta1-3gamma2L but not alpha3/5beta1-3gamma2L receptors expressed in Xenopus oocytes. 3-hydroxy-2'-methoxy-6-methylflavone MGC75582, possible similarity to act2 S homeolog Xenopus laevis
4 Here we demonstrate that the synthetic flavonoid, 3-hydroxy-2"-methoxy-6-methylflavone (3-OH-2"MeO6MF) potentiates GABA-induced currents at recombinant alpha1/2beta2, alpha1/2/4/6beta1-3gamma2L but not alpha3/5beta1-3gamma2L receptors expressed in Xenopus oocytes. gamma-Aminobutyric Acid MGC75582, possible similarity to act2 S homeolog Xenopus laevis