Title : Gene repressive activity of RIP140 through direct interaction with CDK8.

Pub. Date : 2011 Oct

PMID : 21868449






5 Functional Relationships(s)
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1 We also uncover direct interaction of RIP140 with cyclin-dependent kinase (CDK)8 through the amino terminus of RIP140, which is stimulated by lysine acetylation on RIP140. Lysine nuclear receptor interacting protein 1 Homo sapiens
2 We also uncover direct interaction of RIP140 with cyclin-dependent kinase (CDK)8 through the amino terminus of RIP140, which is stimulated by lysine acetylation on RIP140. Lysine nuclear receptor interacting protein 1 Homo sapiens
3 We also uncover direct interaction of RIP140 with cyclin-dependent kinase (CDK)8 through the amino terminus of RIP140, which is stimulated by lysine acetylation on RIP140. Lysine nuclear receptor interacting protein 1 Homo sapiens
4 We further validate the biological activity of lysine acetylation-mimetic RIP140, which elicits a stronger repressive effect and more efficiently recruits CDK8 and confirm CDK8"s function in recruiting repressive components, such as G9a, to the RIP140 complex on this promoter. Lysine nuclear receptor interacting protein 1 Homo sapiens
5 We further validate the biological activity of lysine acetylation-mimetic RIP140, which elicits a stronger repressive effect and more efficiently recruits CDK8 and confirm CDK8"s function in recruiting repressive components, such as G9a, to the RIP140 complex on this promoter. Lysine nuclear receptor interacting protein 1 Homo sapiens