Title : Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity.

Pub. Date : 2011 Aug 11

PMID : 21833028






6 Functional Relationships(s)
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1 In mice, lovastatin mitigated acute doxorubicin-induced heart and liver damage as indicated by reduced mRNA levels of the pro-fibrotic cytokine connective tissue growth factor (CTGF) and pro-inflammatory cytokines, respectively. Lovastatin cellular communication network factor 2 Mus musculus
2 In mice, lovastatin mitigated acute doxorubicin-induced heart and liver damage as indicated by reduced mRNA levels of the pro-fibrotic cytokine connective tissue growth factor (CTGF) and pro-inflammatory cytokines, respectively. Lovastatin cellular communication network factor 2 Mus musculus
3 In mice, lovastatin mitigated acute doxorubicin-induced heart and liver damage as indicated by reduced mRNA levels of the pro-fibrotic cytokine connective tissue growth factor (CTGF) and pro-inflammatory cytokines, respectively. Doxorubicin cellular communication network factor 2 Mus musculus
4 In mice, lovastatin mitigated acute doxorubicin-induced heart and liver damage as indicated by reduced mRNA levels of the pro-fibrotic cytokine connective tissue growth factor (CTGF) and pro-inflammatory cytokines, respectively. Doxorubicin cellular communication network factor 2 Mus musculus
5 Lovastatin also protected from doxorubicin-provoked subacute cardiac damage as shown by lowered mRNA levels of CTGF and atrial natriuretic peptide. Lovastatin cellular communication network factor 2 Mus musculus
6 Lovastatin also protected from doxorubicin-provoked subacute cardiac damage as shown by lowered mRNA levels of CTGF and atrial natriuretic peptide. Doxorubicin cellular communication network factor 2 Mus musculus