Title : Aspartoacylase-lacZ knockin mice: an engineered model of Canavan disease.

Pub. Date : 2011

PMID : 21625469






10 Functional Relationships(s)
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1 Canavan Disease (CD) is a recessive leukodystrophy caused by loss of function mutations in the gene encoding aspartoacylase (ASPA), an oligodendrocyte-enriched enzyme that hydrolyses N-acetylaspartate (NAA) to acetate and aspartate. N-acetylaspartate aspartoacylase Mus musculus
2 Canavan Disease (CD) is a recessive leukodystrophy caused by loss of function mutations in the gene encoding aspartoacylase (ASPA), an oligodendrocyte-enriched enzyme that hydrolyses N-acetylaspartate (NAA) to acetate and aspartate. N-acetylaspartate aspartoacylase Mus musculus
3 Canavan Disease (CD) is a recessive leukodystrophy caused by loss of function mutations in the gene encoding aspartoacylase (ASPA), an oligodendrocyte-enriched enzyme that hydrolyses N-acetylaspartate (NAA) to acetate and aspartate. Acetates aspartoacylase Mus musculus
4 Canavan Disease (CD) is a recessive leukodystrophy caused by loss of function mutations in the gene encoding aspartoacylase (ASPA), an oligodendrocyte-enriched enzyme that hydrolyses N-acetylaspartate (NAA) to acetate and aspartate. Aspartic Acid aspartoacylase Mus musculus
5 X-Gal staining in known ASPA expression domains confirms the integrity of the modified locus in heterozygous aspa lacZ-knockin (aspa(lacZ/+)) mice. 5-bromo-4-chloro-3-indolyl beta-galactoside aspartoacylase Mus musculus
6 X-Gal staining in known ASPA expression domains confirms the integrity of the modified locus in heterozygous aspa lacZ-knockin (aspa(lacZ/+)) mice. 5-bromo-4-chloro-3-indolyl beta-galactoside aspartoacylase Mus musculus
7 X-Gal staining in known ASPA expression domains confirms the integrity of the modified locus in heterozygous aspa lacZ-knockin (aspa(lacZ/+)) mice. 5-bromo-4-chloro-3-indolyl beta-galactoside aspartoacylase Mus musculus
8 Non-invasive ultrahigh field proton magnetic resonance spectroscopy revealed increased levels of NAA, myo-inositol and taurine in the aspa(lacZ/lacZ) brain. N-acetylaspartate aspartoacylase Mus musculus
9 Non-invasive ultrahigh field proton magnetic resonance spectroscopy revealed increased levels of NAA, myo-inositol and taurine in the aspa(lacZ/lacZ) brain. Inositol aspartoacylase Mus musculus
10 Non-invasive ultrahigh field proton magnetic resonance spectroscopy revealed increased levels of NAA, myo-inositol and taurine in the aspa(lacZ/lacZ) brain. Taurine aspartoacylase Mus musculus