Title : CHFR binds to and regulates MAD2 in the spindle checkpoint through its cysteine-rich domain.

Pub. Date : 2011 Jun 10

PMID : 21575600






2 Functional Relationships(s)
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1 Furthermore, the cysteine-rich domain deletion exhibits impaired ability to promote the MAD2/CDC20 interaction, leading to an increase in mitotic defects relative to wild type CHFR. Cysteine cell division cycle 20 Homo sapiens
2 Furthermore, these data establish the cysteine-rich domain of CHFR as the essential domain for the CHFR/MAD2 interaction and for promoting interaction between MAD2 and CDC20 to inhibit the anaphase-promoting complex. Cysteine cell division cycle 20 Homo sapiens