Title : AKAP150-mediated TRPV1 sensitization is disrupted by calcium/calmodulin.

Pub. Date : 2011 May 14

PMID : 21569553






3 Functional Relationships(s)
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1 RESULTS: In trigeminal neurons, intracellular accumulation of calcium reduced AKAP150 association with TRPV1 in a manner sensitive to calmodulin antagonism. Calcium LOC100759184 Cricetulus griseus
2 In CHO cells, the deletion of the C-terminal calmodulin-binding site of TRPV1 resulted in greater association with AKAP150, and increased channel activity. cho LOC100759184 Cricetulus griseus
3 Furthermore, the co-expression of wild-type calmodulin in CHOs significantly reduced TRPV1 association with AKAP150, as evidenced by total internal reflective fluorescence-fluorescence resonance energy transfer (TIRF-FRET) analysis and electrophysiology. CAV protocol LOC100759184 Cricetulus griseus