Title : [Effect and mechanisms of rutaecarpine on treating atopic dermatitis in mice].

Pub. Date : 2011 Mar

PMID : 21500561






4 Functional Relationships(s)
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1 The animal model of atopic dermatitis treated with Rutaecarpine had higher levels of plasma IFN-gamma level [(68.29 +/- 1.39) pg/mL] than those without treatment [(51.23 +/- 11.45) pg/mL]. rutecarpine interferon gamma Mus musculus
2 The animal model of atopic dermatitis treated with Rutaecarpine had lower levels of plasma IL-4 and IgE [(72.11 +/- 2.13) pg/mL and (69.17 +/- 4.15) ng/mL, respectively] than those without treatment [(95.49 +/- 6.32) pg/mL and (124.42 +/- 11.14) ng/mL, respectively, P < 0.05]. rutecarpine interleukin 4 Mus musculus
3 CONCLUSION: The therapeutic effect of Rutaecarpine on atopic dermatitis-like skin lesions may be taken through inhibiting IgE and IL-4 synthesis and promoting the secretion of IFN-gamma. rutecarpine interleukin 4 Mus musculus
4 CONCLUSION: The therapeutic effect of Rutaecarpine on atopic dermatitis-like skin lesions may be taken through inhibiting IgE and IL-4 synthesis and promoting the secretion of IFN-gamma. rutecarpine interferon gamma Mus musculus