Title : Ghrelin receptor modulators and their therapeutic potential.

Pub. Date : 2009 Apr

PMID : 21426074






1 Functional Relationships(s)
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1 DISCUSSION: The latest developments in this field are constituted by the discovery of new nonpeptidic compounds endowed with interesting properties: oxindole agonists are able to exert an increase in the fat-free mass, while ghrelin was reported to increase the fat mass gain, and triazole- and 2,4-diaminopyrimidine-based antagonists were shown to be able to reduce food intake, without inhibition of GH secretion stimulated by an agonist to the ghrelin receptor. 2-oxindole growth hormone secretagogue receptor Homo sapiens