Title : Ubiquitously expressed hematological and neurological expressed 1 downregulates Akt-mediated GSK3β signaling, and its knockdown results in deregulated G2/M transition in prostate cells.

Pub. Date : 2011 Jun

PMID : 21323578






2 Functional Relationships(s)
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1 Additionally, HN1 was found to be downregulated by the specific AKT inhibitor wortmannin but not with PI3K or MAPK inhibitors, LY294002 and PD98059, respectively, in PC-3 and MCF-7 cells. Wortmannin Jupiter microtubule associated homolog 1 Homo sapiens
2 Consistently, overexpression of HN1 reversed the cell-cycle-specific observations, resulted in accumulation of cells in G(2)/M, and reduced the proliferation rate, which were investigated using flow cytometry and methylthiazol tetrazolium assays. methylthiazol tetrazolium Jupiter microtubule associated homolog 1 Homo sapiens