Title : Synthesis and biological evaluation of 2'-oxo-2,3-dihydro-3'H- spiro[chromene-4,5'-[1,3]oxazolidin]-3'yl]acetic acid derivatives as aldose reductase inhibitors.

Pub. Date : 2011 Jun

PMID : 21319207






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Aldose reductase (ARL2) is the first enzyme in the polyol pathway which catalyzes the NADPH-dependent reduction of glucose to sorbitol. NADP ADP ribosylation factor like GTPase 2 Homo sapiens
2 Aldose reductase (ARL2) is the first enzyme in the polyol pathway which catalyzes the NADPH-dependent reduction of glucose to sorbitol. Glucose ADP ribosylation factor like GTPase 2 Homo sapiens
3 Aldose reductase (ARL2) is the first enzyme in the polyol pathway which catalyzes the NADPH-dependent reduction of glucose to sorbitol. Sorbitol ADP ribosylation factor like GTPase 2 Homo sapiens
4 On this basis, a limited series of 4-spiro-oxazolidinone-benzopyran derivatives (1-7) were synthesized to evaluate them as potential ARL2 inhibitors. 4-spiro-oxazolidinone-benzopyran ADP ribosylation factor like GTPase 2 Homo sapiens