Title : Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts.

Pub. Date : 1990 Dec 1

PMID : 2124251






2 Functional Relationships(s)
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1 The present study demonstrates that murine dermal fibroblasts produce nitrite (NO2-) and nitrate (NO3-) upon treatment with interferon gamma (IFN-gamma). Nitrogen Dioxide interferon gamma Mus musculus
2 Inhibition of guanosine triphosphate-cyclohydrolase I, the key enzyme of tetrahydrobiopterin de novo synthesis with 2,4-diamino-6-hydroxy-pyrimidine, leads to decreased formation of NO2- and NO3-. Nitrogen Dioxide NBL1, DAN family BMP antagonist Mus musculus