Title : G-proteins and phospholipase activation in endothelial cells.

Pub. Date : 1990

PMID : 2122640






4 Functional Relationships(s)
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Protein Name
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1 ATP stimulates arachidonic acid release and prostaglandin biosynthesis (most likely via phospholipase A2 (PLA2) activation) and phospholipase C (PLC) activation in cultured rabbit coronary microvessel endothelial cells. Adenosine Triphosphate LOC100009319 Oryctolagus cuniculus
2 In contrast, activation of G-proteins with GTP tau S or AlF4- stimulates both prostaglandin synthesis and PLC. Guanosine Triphosphate LOC100009319 Oryctolagus cuniculus
3 In contrast, activation of G-proteins with GTP tau S or AlF4- stimulates both prostaglandin synthesis and PLC. tetrafluoroaluminate LOC100009319 Oryctolagus cuniculus
4 These observations suggest that PLC activation by ATP involves a G-protein(s) that is not ADP-ribosylated by pertussis toxin and further, that ATP activation of prostaglandin biosynthesis appears to involve a different, pertussis toxin sensitive, G-protein. Adenosine Triphosphate LOC100009319 Oryctolagus cuniculus