Pub. Date : 2011 May
PMID : 21193983
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mice lacking adenylyl cyclase type 5 (AC5) show increased ethanol consumption and reduced ethanol sensitivity. | Ethanol | adenylate cyclase 5 | Mus musculus |
| 2 | Mice lacking adenylyl cyclase type 5 (AC5) show increased ethanol consumption and reduced ethanol sensitivity. | Ethanol | adenylate cyclase 5 | Mus musculus |
| 3 | AC5 has been shown to be an essential mediator of morphine addiction and dopamine receptor function; however, it remains unknown whether or not AC5 plays a role in ethanol preference and sensitivity in animals. | Morphine | adenylate cyclase 5 | Mus musculus |
| 4 | OBJECTIVE: This work was carried out to determine the role of AC5 in alcohol consumption and the hypnotic response to alcohol using AC5 knockout (KO) mice. | Alcohols | adenylate cyclase 5 | Mus musculus |
| 5 | RESULTS: In the test for ethanol preference employing a two-bottle free-choice paradigm, AC5 KO mice showed increased ethanol consumption and preference compared with the wild-type mice. | Ethanol | adenylate cyclase 5 | Mus musculus |
| 6 | RESULTS: In the test for ethanol preference employing a two-bottle free-choice paradigm, AC5 KO mice showed increased ethanol consumption and preference compared with the wild-type mice. | Ethanol | adenylate cyclase 5 | Mus musculus |
| 7 | Ethanol-induced hypothermia was weakly reduced in AC5 KO mice. | Ethanol | adenylate cyclase 5 | Mus musculus |
| 8 | AC5 KO mice exhibited sedation/behavioral sleep to high-dose ethanol, but their responses were greatly suppressed compared with the wild-type mice. | Ethanol | adenylate cyclase 5 | Mus musculus |
| 9 | CONCLUSIONS: These results suggest that AC5 is an important signaling molecule regulating alcohol sensitivity and preference in animals. | Alcohols | adenylate cyclase 5 | Mus musculus |